To prepare and submit Syrup of Ephedrine HCl IP (20 ml)

To prepare and submit Syrup of Ephedrine HCl IP (20 ml)

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Aim:

To prepare and submit Syrup of Ephedrine HCl IP (20 ml)

Requirements:

Ephedrine HCl, beaker, stirrer, spatula, measuring cylinder, and purified water.

Principle:

Syrups are sweetened, viscous, concentrated solutions of sucrose or, other sugars in water or any other suitable aqueous vehicles. These are further classified into 2 classes.
1. Simple flavored syrups
2. Medicated syrups
Simple flavor syrups: Do not contain any medicament or drug. These syrups are used as a vehicle for other Liquid preparation to mask the disagreeable taste of drug.
Medicated syrups: These contain some medicinal substance along with their other additives. Sucrose concentration in simple syrup is a 66.7%w/w.

Procedure:

1. Add water to Ephedrine HCl in a beaker and heat on water bath until sucrose dissolves add sufficient boiling water to produce the final volume.
2. Filter hot syrup through cotton wool. Cool the syrup and preservatives may be added for stability.

         S.no Ingredients Official quantities Required quantities (20 ml)
             1. Ephedrine HCl         0.025 mg                  0.00075 mg
            2. Distilled water         1000ml                    30ml

Note : calculations are tentative

LABEL:

Use:

Bronchodilator(Bronchodilators are a type of medication that make breathing easier by relaxing the muscles in the lungs and widening the airways (bronchi). They’re often used to treat long-term conditions where the airways may become narrow and inflamed, such as asthma, a common lung condition caused by inflammation of the airways.)

Storage:

Stored in a well-closed container at a temperature not exceeding 25 degree celcius.

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