Table of Contents
Aim:
To prepare and submit Piperazine citrate elixir BP (20 ml)
Requirements:
Piperazine citrate, chloroform spirit, orange oil, syrup, Glycerin, beaker, stirrer, spatula, measuring cylinder, and purified water.
Principle:
Elixirs are clear, flavored, sweetened hydroalcoholic liquid preparations for oral administration. The Percentage of alcohol varies from 4 to 40 %. In this elixirs Propylene glycol, ethanol, and glycerol these are all acts a vehicle and co-solvent to increase the solubility of poorly soluble ingredients. Chloroform spirit acts as a preservative. Invert syrup acts as a sweetening agent.
Formulation Table :
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Ingredients | Â Â Â Â Â Â Â Â Â Â Quantity Prescribed
               (1000 ml) |
 Quantity taken       (20 ml) |
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Piperazine Citrate | Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 180 gm | |
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Chloroform spirit | Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 5 ml | |
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Glycerin | Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 100 ml | |
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Orange oil | Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 0.25 ml | |
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Syrup | Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 500 ml | |
| Â Â Â Â Â Â Â Â Â Â Â Â Â Â Purified water up to | Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â 1000 ml |
Note : All calculation will be done by student itself & the quantities of ingredients are tentative and depends on the experiment performer.
Procedure
- Â Piperazine citrate is dissolved in small amount of purified water.
- Orange oil, glycerin, syrup and chloroform spirit is mixed.
- Sufficient volume is added to produce the final volume.
LABEL:
Use:
Anthelmentic
Storage
Stored in a well closed container at a temperature not exceeding 25 0C.
